The 2-1-2 basketball zone defense is strong underneath against good pivot players. It is especially strong in the rebounding triangle area. It is also an excellent defense to use if you want to fast break as it allows one man, usually X1, to break as soon as the offensive team shoots the ball. This is often called, "cherry picking."

The two-one-two is vulnerable from the weak side along the baseline from jump shooters on the side at a forty-five-degree angle, from the medium shooting areas, and the top of the key.

X1 and X2 should both be aggressive guards. X5 should be your tallest player with the longest arms; X4 should be your best rebounding forward, and X3 the more mobile forward.